描述
开 本: 16开纸 张: 胶版纸包 装: 平装-胶订是否套装: 否国际标准书号ISBN: 9787302491538丛书名: 普通高等教育”十三五”规划教材.全国高等医药院校规划教材
随着核医学显像设备SPECT及PET的逐步普及应用，核医学与临床各学科的关系日趋密切。核医学分子影像成为影像诊断中不可或缺的部分。该教材除了注重核医学基础理论、基本技术及核医学在各系统的临床应用外，重点按系统编写，内容主要根据临床实用与需要考虑。为加深学生对核医学影像的认识和理解，精选大量原始彩色插图，深入浅出，让读者易懂易学。此外，也突出了核素治疗在临床核医学中的重要地位，体现出临床核医学是一门诊断与治疗并重的学科。
Contents
目录
PartⅠ Basic Principles
Chapter 1 Physics of Nuclear Medicine 3
RADIoACTIvITY AND RADIoACTIvE DECAY 3
INTERACTIoNS BETWEEN RADIATIoN AND MATTER 7
SUGGESTED READING 12
Chapter 2 Radiopharmaceuticals 13
ElEMENTS, RADIoNUClIDES, AND RADIoPHARMACEUTICAlS 13
PRoDUCTIoN oF RADIoNUClIDES 14
RADIoNUClIDE GENERAToRS 15
TECHNETIUM CHEMISTRY AND RADIoPHARMACEUTICAl PREPARATIoN 16
QUAlITY ASSURANCE oF TECHNETIUM-99M—lABElED RADIoPHARMACEUTICAlS 16
SINGlE-PHoToN RADIoPHARMACEUTICAlS oTHER THAN TC-99M 17
DUAl PHoToN RADIoPHARMACEUTICAlS FoR PoSITRoN EMISSIoN ToMoGRAPHY 18
DISPENSING RADIoPHARMACEUTICAlS 18
SUGGESTED READING 19
Chapter 3 Radiation Detection and Instrumentation 20
CHARATERISTICS oF A RADIATIoN DETECToR 20
TYPES oF RADIATIoN DETECToRS 21
ANCIllARY EQUIPMENT 22
NUClEAR MEDICINE IMAGING 23
SUMMARY 27
SUGGESTED READING 28
Chapter 4 Single-Photon Emission Computed Tomography, Positron
Emission Tomography, and Hybrid Imaging 29
IMAGE RECoNSTRUCTIoN 29
SINGlE-PHoToN EMISSIoN CoMPUTED ToMoGRAPHY 35
PoSITRoN EMISSIoN ToMoGRAPHY 35
HYBRID PoSITRoN EMISSIoN
CoMPUTED ToMGRAPHY, SINGlEPHoToN CoMPUTED ToMoGRAPHY WITH CoMPUTED ToMoGRAPHY,
AND PoSITRoN EMISSIoN ToMoGRAPHY WITH MAGNETIC RESoNANCE 36 SUGGESTED READING 37
Chapter 5 Molecular Imaging 38
IMAGING TECHNIQUES 38
BIoMARkERS 39
REPoRTER GENE IMAGING AND GENE THERAPY 42
SUGGESTED READING 43
Part Ⅱ Clinical Nuclear Medicine
Chapter 6 Central Nervous System 47
CEREBRAl ANAToMY 47
CEREBRAl BlooD FloW AND METABolISM 48
ClINICAl APPlICATIoNS FoR CEREBRAl PERFUSIoN IMAGING 51
MovEMENT DISoRDERS 62
AMYloID IMAGING 63
CISTERNoGRAPHY 64
SUGGESTED READING 68
Chapter 7 Cardiac System 69
MYoCARDIAl PERFUSIoN SCINTIGRAPHY 69
PoSITRoN EMISSIoN ToMoGRAPHY oF THE HEART 97
RADIoNUClIDE vENTRICUloGRAPHY 104
MYoCARDIAl INFARCT AND AMYloIDoSIS IMAGING 111
SUGGESTED READING 111
Chapter 8 Endocrine System 113
THYRoID SCINTIGRAPHY AND UPTAkE STUDIES 113
PARATHYRoID SCINTIGRAPHY 121
SUGGESTED READING 124
Chapter 9 Oncology: Positron Emission Tomography 125
BACkGRoUND 125
IMAGE INTERPRETATIoN 127
ClINICAl USES oF PoSITRoN EMISSIoN ToMoGRAPHY IN oNColoGY 134
SUGGESTED READING 151
Chapter 10 Oncology: Non–Positron Emission Tomography 152
PEPTIDE RECEPToR IMAGING 152
ADRENAl SCINTIGRAPHY 154
MoNoCloNAl ANTIBoDY IMAGING AND THERAPY 156
NoNSPECIFIC BINDING TUMoR AGENTS 160
lYMPHoSCINTIGRAPHY: THE SENTINEl lYMPH NoDE 162
INTRAARTERIAl RADIoACTIvE MICRoSPHERES 164
BoNE PAIN PAllIATIoN 165
SUGGESTED READING 167
Chapter 11 Skeletal Scintigraphy 169
BoNE SCAN 169
ClINICAl APPlICATIoN oF SkElETAl SCINTIGRAPHY 176
BoNE INFARCTIoN AND oSTEoNECRoSIS 191
oSTEoMYElITIS 193
FloURINE-18 SoDIUM FlUoRIDE PoSITRoN EMISSIoN ToMoGRAPHY 196
BoNE MINERAl MEASUREMENT 197
SUGGESTED READING 198
Chapter 12 Pulmonary System 199
PUlMoNARY EMBolISM 199
vENTIlATIoN PERFUSIoN SCINTIGRAPHY 199
RADIoPHARMACEUTICAlS 200
IMAGE INTERPRETATIoN 203
vENTIlATIoN-PERFUSIoN INTERPRETATIoN CRITERIA 207
oTHER ADDITIoNAl v/Q INTERPRETATIoN CRITERIA 212
SUGGESTED READING 212
Chapter 13 Infection and Inflammation 213
RADIoPHARMACEUTICAlS 213
ClINICAl APPlICATIoNS FoR INFECTIoN SCINTIGRAPHY 218
SUGGESTED READING 226
Chapter 14 Gastrointestinal System 227
ESoPHAGEAl MoTIlITY 227
GASTRoESoPHAGEAl REFlUX DISEASE 230
GASTRIC MoTIlITY SCINTIGRAPHY 231
INTESTINAl TRANSIT SCINTIGRAPHY 237
PRoTEIN-loSING ENTERoPATHY 239
HElICoBACTER PYloRI INFECTIoN 239
GASTRoINTESTINAl BlEEDING 239
HETERoToPIC GASTRIC MUCoSA 245
SUGGESTED READING 248
Chapter 15 Hepatobiliary System 249
CHolESCINTIGRAPHY 249
TECHNETIUM-99M RED BlooD CEll lIvER SCINTIGRAPHY 267
TECHNETIUM-99M SUlFUR ColloID lIvER AND SPlEEN IMAGING 270
SPlEEN SCINTIGRAPHY 272
TECHNETIUM-99M MACRoAGGREGATED AlBUMIN HEPATIC ARTERIAl PERFUSIoN
SCINTIGRAPHY 274
SUGGESTED READING 275
Chapter 16 Genitourinary System 277
RENAl ANAToMY AND FUNCTIoN 277
RENAl RADIoPHARMACEUTICAlS 278
DYNAMIC RENAl IMAGING TECHNIQUES 283
MEASURING RENAl
FUNCTIoN:EFFECTIvE RENAl PlASMA FloW(ERPF)AND GloMERUlAR
FIlTRATIoN RATE (GFR) 292
RENAl CoRTICAl IMAGING 292
SUGGESTED READING 294
Part Ⅲ Radionuclide Therapy Chapter 17
Nuclear Medicine Therapy 297
RADIoIoDINE THEARPY FoR HYPERTHYRoIDISM 297
MANAGEMENT oF HYPERTHYRoIDISM DUE To ToXIC MUlTINoDUlAR GoITER AND
ToXIC
ADENoMA 300
MANAGEMENT oF GD IN CHIlDREN AND ADolESCENTS 301
CANCER RISk AND RADIATIoN SAFETY REGARDING RADIoIoDINE THEARPY FoR
HYPERTHYRoIDISM 301
RADIoIoDINE THERAPY FoR THYRoID CANCER 302
METASTATIC BoNE PAIN THERAPY 309
SUGGESTED READING 311
The applications of Nuclear Medicine in
different medical disciplines have kept increasing in the past several decades.
As an important part of molecular imaging, SPECT/CT and PET/ CT have become
commonly used in Nuclear Medicine imaging modality. Nuclear Medicine, as an
important medical knowledge, has been independently and widely learned by
medical students including overseas students. More and more overseas students
come to China to learn medicine in recent years. Most of them apply for
Bachelor’ degree. It is necessary to edit an English textbook of Nuclear
Medicine for the undergraduate program. Physicians from Nuclear Medicine
department of Tianjin Medical University General Hospital have been devoted to
Nuclear Medicine education since the 1980s. Supported and organized by Tsinghua
University Press and Tianjin Medical University, twelve Nuclear Medicine
experts and scholars from nine universities in China make contributions to this
textbook, which is based on Nuclear Medicine The requisites(edition 4) written
by Harvey A. Ziessman MD and published by Saunders.
In order to meet the basic needs of both
international and domestic medical students, necessary adaptations and
revisions are carefully made from the original book. In addition, we reorganize
the chapters and make a new chapter of radionuclide therapy in order to give
students a systemic knowledge in this field. This new textbook covers three
parts, including Basic Principles, Clinical Nuclear Medicine and Radionuclide
Therapy. The chapters follow an outline format and the main section (Clinical
Nuclear Medicine) are divided by organ-systems (i.e., Central Nervous System,
Cardiac System, Endocrine System, etc).
Although this edition is primarily designed
for overseas medical students, it is also a good reference book for Nuclear
Medicine physicians and technicians, resident doctors in other specialties. We
hope it is helpful to all the readers. We would like to share our limited
knowledge and experience with the readers. Comments and suggestions for this
book are always welcome.
In compiling this book, we received
assistance from many sources, and would like to thank those people for their
supports.
Editors July 8,2017
Chapter 1
Physics of Nuclear Medicine
Nuclear medicine involves the administration of 160 radiopharmaceuticals to patients for diagnostic and therapeutic purposes. For diagnostic imaging, 140 radiation emitted from these radiopharmaceuticals must be detected by external detectors to determine 120 its in vivo distribution. For therapeutic nuclear medicine, some of the emitted radiation must be 100 absorbed by targeted tissues to achieve the desired effect. In both cases, an understanding of the nature of the radioactivity, the amount administered, the radiation emissions, and how it interacts with matter is essential. The essential aspects of the basic physics
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