描述
开 本: 16开纸 张: 铜版纸包 装: 精装是否套装: 否国际标准书号ISBN: 9787550293625
经典名著 《Williams血液学》是血液学领域公认的经典之作，经过多次修订，指导了一代又一代的临床医生、生物学研究者和众多学科的实习生。作者们均是各自领域的学术带头人，他们的基础和临床成果得到了国际广泛认可。
内容全面 共139章，涵盖了血液学的所有方面。前半部分讨论了患者临床评估、血液病的分子学和细胞学基础，后半部分具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓，以及输血医学。包含彩图1300余幅。
与时俱进 《Williams血液学（第9版）》在基础科学、转换病理生理学和临床实践方面做了大篇幅的修改和更新，以反映血液学领域*的研究进展。
印刷精美 全书彩色印刷，包含大量极具诊断价值的细胞形态学图片，使阅读和查找更加直观、方便。
《Williams血液学》是血液学领域的经典之作，涵盖了血液学的所有方面，介绍了患者临床评估、血液病的分子学和细胞学基础，并具体阐述了红细胞疾病、粒细胞和单核细胞疾病、淋巴细胞和浆细胞疾病、髓系肿瘤性疾病、淋巴组织疾病、止血和血栓、输血医学等内容。第9版在第8版的基础上做了大篇幅的修改和更新，以反映血液学领域的*进展。新增加了表观遗传学和基因组学、血液肿瘤细胞的新陈代谢和肝素诱导性血小板减少症等内容。本书是血液科临床医生、实习生、血液学研究人员必不可少的案头佳作，也是学习血液学专业英语的工具书。
简 目
Contributors
Preface
PART IClinical Evaluation
of the Patient
PARTII TheOrganization of the LymphohematopoieticTissues
PARTIII
EpochalHematology
PARTIV
Molecular and CellularHematology
PARTV TherapeuticPrinciples
PARTVI The Erythrocyte
PARTVII Neutrophils,Eosinophils,Basophils, and Mast
Cells
PARTVIII
Monocytes and Macrophages
PARTIX Lymphocytes and Plasma Cells
PARTX MalignantMyeloid Diseases
PARTXI MalignantLymphoid Diseases
PARTXII Hemostasis andThrombosis
PARTXIII Transfusion Medicine
Index
v
目 录
Contributors. . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. .ix
Preface. . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . .xxi
PART I
ClinicalEvaluation of the Patient
1.InitialApproachto the Patient:HistoryandPhysicalExamination
2.Examinationof Blood Cells
3.ExaminationofTheMarrow
4.ConsultativeHematology
PART II
TheOrganization of the LymphohematopoieticTissues
5.Structureof the Marrowand the HematopoieticMicroenvironment
6.The Organization
and StructureofLymphoid
Tissues
PART III
Epochal Hematology
7.Hematologyof the FetusandNewborn
8.HematologyduringPregnancy
9.Hematology in OlderPersons
PART IV
Molecular and CellularHematology
10.Genetic PrinciplesandMolecular Biology
11.Genomics
12.Epigenetics
13.Cytogeneticsand Genetic Abnormalities
14.MetabolismofHematologicNeoplastic Cells
15.ApoptosisMechanisms:Relevanceto the HematopoieticSystem
16.Cell-CycleRegulationandHematologicDisorders
17.SignalTransductionPathways
18.HematopoieticStem Cells, Progenitors,andCytokines
19.TheInflammatory
Response
20.InnateImmunity
21.Dendritic Cells andAdaptiveImmunity
PARTV
TherapeuticPrinciples
22.PharmacologyandToxicityofAntineoplastic Drugs
23.Hematopoietic Cell Transplantation
24.Treatment of InfectionsinTheImmunocompromisedHost
25.AntithromboticTherapy
26.Immune Cell Therapy
27.VaccineTherapy
28.TherapeuticApheresis:Indications,Efficacy,andComplications
29.Gene TherapyforHematologicDiseases
30.RegenerativeMedicine:MultipotentialCellTherapy for
TissueRepair
PARTVI
The Erythrocyte
31.StructureandCompositionof the Erythrocyte
32.Erythropoiesis
33.Erythrocyte Turnover
34.ClinicalManifestations and Classification ofErythrocyteDisorders
35.AplasticAnemia:Acquiredand Inherited.
36. Pure Red Cell Aplasia
37. Anemia of
ChronicDisease
38.
The Congenital
DyserythropoieticAnemias
39. Paroxysmal
Nocturnal Hemoglobinuria
40. ParoxysmalNocturnalHemoglobinuria
41. Folate,Cobalamin,andMegaloblasticAnemias
42.IronMetabolism
43.Iron Deficiency andOverload
44. Anemia
Resulting fromOtherNutritionalDeficiencies
45. Anemia
AssociatedwithMarrowInfiltration
46. Erythrocyte MembraneDisorders
47. Erythrocyte Enzyme Disorders
48. TheThalassemias:
Disorders of GlobinSynthesis
49. DisordersofHemoglobinStructure:Sickle CellAnemiaandRelatedAbnormalities
50. Methemoglobinemiaand Other Dyshemoglobinemias
51. FragmentationHemolyticAnemia
52. Erythrocyte Disordersas a ResultofChemicalandPhysicalAgents
53. HemolyticAnemiaResultingfromInfectionswithMicroorganisms
54. HemolyticAnemiaResultingfromImmuneInjury
55. AlloimmuneHemolytic Disease of the FetusandNewborn
56. HypersplenismandHyposplenism
57. Primary and Secondary Erythrocytoses
58.ThePorphyrias
59.PolyclonalandHereditarySideroblasticAnemias
PARTVII
Neutrophils,Eosinophils,Basophils, and Mast Cells
60. StructureandCompositionofNeutrophils,Eosinophils,andBasophils
61. Production,Distribution,andFateofNeutrophils
62. EosinophilsandRelatedDisorders
63. Basophils,Mast Cells, andRelatedDisorders
64. Classificationand
Clinical ManifestationsofNeutrophilDisorders
65. NeutropeniaandNeutrophilia
66. DisordersofNeutrophilFunction
PARTVIII
Monocytes and Macrophages
67. Structure,Receptors,andFunctionsofMonocytesandMacrophages
68. Production,Distribution,andActivationofMonocytesandMacrophages
69. Classificationand
ClinicalManifestationsof DisordersofMonocytesandMacrophages
70. MonocytosisandMonocytopenia
71. Inflammatory
andMalignantHistiocytosis
72. Gaucher Disease andRelatedLysosomalStorageDiseases
73. PART IX
Lymphocytes and Plasma Cells
73.The
StructureofLymphocytes andPlasma Cells
74.LymphopoiesisFunctionsof B LymphocytesandPlasma
Cells inImmunoglobulinProduction
75. Functionsof T Lymphocytes:T-CellReceptorsforAntigen
76. FunctionsofNaturalKiller Cells
77. Classificationand
Clinical ManifestationsofLymphocyteandPlasma Cell Disorders
79.LymphocytosisandLymphocytopenia
80.Immunodeficiency
Diseases
81.HematologicManifestationsofAcquiredImmunodeficiencySyndrome
82.MononucleosisSyndromes
PART X
MalignantMyeloid Diseases
83.Classification
and ClinicalManifestationsoftheClonalMyeloidDisorders
84.PolycythemiaVera
85.EssentialThrombocythemia
86.Primary Myelofibrosis
87.MyelodysplasticSyndromes
88.AcuteMyelogenousLeukemia
89.ChronicMyelogenousLeukemiaandRelatedDisorders
PART XI
MalignantLymphoid Diseases
90.ClassificationofMalignantLymphoid Disorders
91.AcuteLymphoblasticLeukemia
92.ChronicLymphocyticLeukemia
93.Hairy Cell Leukemia
94.LargeGranularLymphocyticLeukemia
95.General ConsiderationsforLymphomas:Epidemiology,Etiology,Heterogeneity,and Primary Extranodal
Disease
96.PathologyofLymphomas.
97.HodgkinLymphoma
98.Diffuse Large B-Cell Lymphoma andRelated Diseases
99.FollicularLymphoma
100.Mantle Cell Lymphoma
101.MarginalZone B-Cell Lymphomas
102.BurkittLymphoma
103.CutaneousT-CellLymphoma(MycosisFungoidesandSézarySyndrome)
104.MatureT-CellandNaturalKiller Cell Lymphomas
105.Plasma Cell Neoplasms:
General Considerations
106.EssentialMonoclonalGammopathy
107.Myeloma.
108.ImmunoglobulinLight-ChainAmyloidosis
109.Macroglobulinemia.
110.Heavy-Chain Disease
PART XII
Hemostasis andThrombosis
111.Megakaryopoiesis
andThrombopoiesis
112.PlateletMorphology,Biochemistry,and Function
113.Molecular Biology andBiochemistryof theCoagulationFactorsandPathwaysofHemostasis
114.ControlofCoagulationReactions
115.VascularFunction in Hemostasis
116.Classification,
Clinical Manifestations, andEvaluationofDisordersofHemostasis
117.Thrombocytopenia
118.Heparin-Induced
Thrombocytopenia
119.ReactiveThrombocytosis
120.HereditaryQualitativePlateletDisorders
121.AcquiredQualitativePlateletDisorders
122.TheVascularPurpuras
123. Hemophilia A andHemophilia B
124. InheritedDeficiencies of
Coagulation FactorsII,V,V VIII, VII, X, XI, and XII
125.
Hereditary Fibrinogen
Abnormalities
126.
von Willebrand
Disease
127. Antibody-Mediated
Coagulation FactorDeficiencies
128. HemostaticAlterations in Liver Disease andLiverTransplantation
129. DisseminatedIntravascularCoagulation
130.HereditaryThrombophilia
131. The AntiphospholipidSyndrome
132. Thrombotic
Microangiopathies
133.VenousThrombosis
134. Atherothrombosis: Disease Initiation,Progression,andTreatment
135. Fibrinolysis
andThrombolysis
PART XIII
Transfusion Medicine
136. Erythrocyte AntigensandAntibodies
137. Human Leukocyte andPlateletAntigens
138. Blood Procurementand Red Cell Transfusion
139. Preservationand Clinical UseofPlatelets
Index
前 言PREFACE
The first edition of Williams
Hematology (né Hematology) was publishedin 1972. This, our 9th edition,
will represent our continued efforts over nearly one-half century to provide
the most current concepts of the pathophysiology and treatment of hematologic
diseases.
The rate of growth in our understanding of diseases of blood cells and
coagulation pathways provides a challenge for editors of a comprehensive
textbook of hematology. The sequencing of individual genomes, analysis of the
“dark DNA” and noncoding RNAs, advances in knowledge in proteomics,
metabolomics, and other “-omics” fields, as applied to hematologic disorders,
have accelerated the understanding of the pathogenesis of the diseases of our
interest. The rate at which basic knowledge in molecular and cellular biology
and immunology has been translated into improved diagnostic and therapeutic
methods is equally impressive. Specific molecular targets for therapy in
several hematologic disorders have become reality, and it is not hyperbole to
state that hematology is the poster child for the rational design of therapeutics
applicable to other fields of medicine.
This edition of Williams Hematology includes
changes designed tofacilitate ease of access to information, both within the
book and its associated links, and has been modestly reorganized to reflect our
greater understanding of the origins of hematologic disorders. Each chapter has
been revised or rewritten to provide current information. Four new chapters
have been added and other notable changes have been made. Chapter 4
“Consultative Hematology” is new to this edition. The chapter “Epigenetics and
Genomics” has been divided into separate chapters to reflect the growth of
knowledge in those disciplines. Chapter 14, “Metabolism of Hematologic
Neoplastic Cells” is new, as this topic has become the basis of multiple
potential drug targets for hematologic disease. A section on “Autophagy” has
been added to Chap 15 “Apoptosis Mechanisms: Relevance to the Hematopoietic
System,” as the topic is becoming increasingly important for understanding of
the physiology of blood cell development; and an independent chapter
“Heparin-Induced Thrombocytopenia” (Chap 118) has been created to reflect both
its pathophysiologic and clinical importance. Recognizing that at the heart of
diagnostic hematology is blood and marrow cell morphology, we have continued
our incorporation of informative color images of the relevant disease topics in
each chapter, allowing easy access to illustrations of cell morphology
important to diagnosis.
The 9th edition of Williams Hematology is also available online,as part of
the excellent www.accessmedicine.com website. With direct links to a
comprehensive drug therapy database and to other important medical texts,
including Harrison’s Principles of Internal Medicine and Goodman and Gilman’sof
Williams Hematology also includes PubMed links to journal articlescited in the
references.
In addition, Williams Manual of Hematology will be revised to reflect the
diagnostic and therapeutic advances incorporated in the 9th edition of Williams
Hematology. The convenient Manual features the most clinically salient content
from the parent text, and is useful in time-restricted clinical situations. The
Manual will be available for iPhone™ and other mobile formats.
The readers of the 9th edition of Williams Hematology will note a“changing of (some of)
the guard” of our editorial group; Drs. Marcel Levi (a member of the 8th
edition of Williams Manual of Hematology editorial group), Oliver Press, Linda
Burns, and Michael Caligiuri have joined continuing editors Drs. Kenneth
Kaushansky, Marshall Lichtman, and Josef Prchal in the 9th edition.
The production of this book required the timely cooperation of 101 contributors
for the production of 139 chapters. We are grateful for their work in providing
this comprehensive and up-to-date text. Despite the growth of both basic and
clinical knowledge and the passion that each of our contributors brings to the
topic of their chapter, we have been able to maintain the text in a single
volume through scrupulous attention to chapter length.
Each editor has had expert administrative assistance in the management of
the manuscripts for which they were primarily responsible. We thank Susan
Madden in Salt Lake City, Utah; Nancy Press and Deborah Lemon in Seattle,
Washington; and Annie Thompson, Rebecca Posey, and Kimberly Morley in Columbus,
Ohio for their very helpful participation in the production of the book.
Special thanks go to Susan Daley in Rochester, New York, and Marie Brito in
Stony Brook, New York, who were responsible for coordinating the management of
139 chapters, including many new figures and tables, and managing other
administrative matters, a challenging task that Ms. Daley and Ms. Brito
performed with skill and good humor.
Kenneth Kaushansky
Marshall A.
Lichtman Joseph T. Prchal
Marcel Levi
Oliver W. Press
Linda J. Burns
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